Publications
Below, you’ll find a selection of our recent publications that highlight our contributions to pediatric oncology research and precision medicine. These papers showcase our commitment to advancing knowledge, developing innovative tools, and collaborating with the broader scientific community. Dive in to explore the insights we’ve gained and the impact we’re making!
Publications by Year
2026
Pan-pediatric brain tumor microRNA networks define immune microenvironment states and responses to CAR T-cell therapy
openRxiv
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23 Oct 2026
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doi:10.64898/2026.10.21.760687
Human leucocyte antigen class I and II alleles are associated with tumor susceptibility in neurofibromatosis type 1
Frontiers in Immunology
·
19 Oct 2026
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doi:10.3389/fimmu.2026.1966259
MOSAIC: Learning Graph Node Embeddings from Spectrally Isolated Dominant Subspaces of Accumulated Diffusion Operators.
bioRxiv : the preprint server for biology
·
06 Oct 2026
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pubmed:42926505
Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets.
Cell reports. Medicine
·
17 Sep 2026
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pubmed:42753723
Tumor Microenvironmental Regulation of CAR T-Cell Therapy in High Risk Medulloblastoma.
Research square
·
21 May 2026
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pubmed:42239754
Alternative splicing in pediatric central nervous system tumors highlights oncofetal candidate
Neuro-oncology pediatrics
·
16 Feb 2026
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pubmed:41908886
Alternative splicing in pediatric central nervous system tumors highlights oncofetal candidate CLK1 exon 4
2025
Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors.
Nature communications
·
21 Nov 2025
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pubmed:41271695
Germline analysis of an international cohort of pediatric diffuse midline glioma patients.
Neuro-oncology
·
08 Sep 2025
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pubmed:40072012
Kinome Reprogramming of G2/M Kinases and Repression of MYCN Contribute to Superior Efficacy of Lorlatinib in ALK-Driven Neuroblastoma.
Molecular cancer therapeutics
·
02 Sep 2025
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pubmed:39907037
NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas.
Cell reports
·
07 Aug 2025
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pubmed:40782352
Imaging Clusters of Pediatric Low-Grade Glioma Are Associated with Distinct Molecular Characteristics.
AJNR. American journal of neuroradiology
·
01 Aug 2025
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pubmed:39952665
Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition.
Clinical cancer research : an official journal of the American Association for Cancer Research
·
14 Apr 2025
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pubmed:39992227
The Open Pediatric Cancer Project
GigaScience
·
01 Jan 2025
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doi:10.1093/gigascience/giaf093
The Open Pediatric Cancer Project
2024
A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma.
Cancer cell
·
24 Oct 2024
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pubmed:39454577
AutoGVP: a dockerized workflow integrating ClinVar and InterVar germline sequence variant classification.
Bioinformatics (Oxford, England)
·
29 Feb 2024
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pubmed:38426335
AutoGVP
BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma.
Journal of the National Cancer Institute
·
10 Jan 2024
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pubmed:37688570
2023
Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
·
17 Nov 2023
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pubmed:37978951
OpenPBTA: The Open Pediatric Brain Tumor Atlas.
Cell genomics
·
31 May 2023
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pubmed:37492101
Identification of candidate genes for nicotine withdrawal in C57BL /6J × DBA /2J recombinant inbred mice
Genes, Brain and Behavior
·
13 Feb 2023
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doi:10.1111/gbb.12844
Identification of candidate genes for nicotine withdrawal in C57BL/6J × DBA/2J recombinant inbred mice.
Genes, brain, and behavior
·
13 Feb 2023
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pubmed:36781202
Enhancing childhood cancer targetability.
Nature cancer
·
01 Feb 2023
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pubmed:36585448
2022
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science.
Neoplasia (New York, N.Y.)
·
03 Nov 2022
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pubmed:36335802
Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003.
Clinical cancer research : an official journal of the American Association for Cancer Research
·
15 Sep 2022
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pubmed:35852795
Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors.
Journal for immunotherapy of cancer
·
01 Sep 2022
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pubmed:36167467
2021
Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.
Cell reports
·
30 Mar 2021
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pubmed:33789113
GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma.
Cancer research
·
18 Feb 2021
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pubmed:33602789
2020
annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions.
BMC bioinformatics
·
14 Dec 2020
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pubmed:33317447
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer.
Cell
·
25 Nov 2020
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pubmed:33242424
A transcriptome-based classifier to determine molecular subtypes in medulloblastoma.
PLoS computational biology
·
29 Oct 2020
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pubmed:33119584
LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase.
Neoplasia (New York, N.Y.)
·
24 Apr 2020
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pubmed:32339949
Limited antitumor activity of combined BET and MEK inhibition in neuroblastoma.
Pediatric blood & cancer
·
19 Apr 2020
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pubmed:32307821
Epigenomic profiling of neuroblastoma cell lines.
Scientific data
·
14 Apr 2020
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pubmed:32286315
Telomere Maintenance Mechanisms Define Clinical Outcome in High-Risk Neuroblastoma.
Cancer research
·
14 Apr 2020
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pubmed:32291317
CAMKV Is a Candidate Immunotherapeutic Target in
Frontiers in oncology
·
06 Mar 2020
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pubmed:32211329
Pediatric high-grade glioma resources from the Children's Brain Tumor Tissue Consortium.
Neuro-oncology
·
11 Jan 2020
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pubmed:31613963
2019
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry.
Nature communications
·
09 Dec 2019
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pubmed:31819055
Combined innate and adaptive immunotherapy overcomes resistance of immunologically cold syngeneic murine neuroblastoma to checkpoint inhibition.
Journal for immunotherapy of cancer
·
06 Dec 2019
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pubmed:31810498
Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.
Cell reports
·
05 Nov 2019
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pubmed:31693904
YAP1 Mediates Resistance to MEK1/2 Inhibition in Neuroblastomas with Hyperactivated RAS Signaling.
Cancer research
·
31 Oct 2019
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pubmed:31672841
Germline 16p11.2 Microdeletion Predisposes to Neuroblastoma.
American journal of human genetics
·
29 Aug 2019
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pubmed:31474320
The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.
Developmental cell
·
28 Mar 2019
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pubmed:30930166
2018
Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.
Cancer discovery
·
06 Mar 2018
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pubmed:29510988
2017
Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma.
Cancer cell
·
11 Sep 2017
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pubmed:28898695
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Scientific data
·
28 Mar 2017
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pubmed:28350380
2016
International Comparison of Enumeration-Based Quantification of DNA Copy-Concentration Using Flow Cytometric Counting and Digital Polymerase Chain Reaction.
Analytical chemistry
·
30 Nov 2016
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pubmed:28193036
Identification of quantitative trait loci and candidate genes for an anxiolytic‐like response to ethanol inBXD recombinant inbred strains
Genes, Brain and Behavior
·
01 Apr 2016
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doi:10.1111/gbb.12289
2015
Inhibition of monoacylglycerol lipase reduces nicotine withdrawal
British Journal of Pharmacology
·
08 Jan 2015
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doi:10.1111/bph.12948
2014
The α3β4* nicotinicACh receptor subtype mediates physical dependence to morphine: mouse and human studies
British Journal of Pharmacology
·
25 Jul 2014
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doi:10.1111/bph.12741
2013
Genetic variation within theChrna7gene modulates nicotine reward‐like phenotypes in mice
Genes, Brain and Behavior
·
26 Dec 2013
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doi:10.1111/gbb.12113
2011
The Neuropeptide Galanin and Variants in the GalR1 Gene are Associated with Nicotine Dependence
Neuropsychopharmacology
·
27 Jul 2011
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doi:10.1038/npp.2011.123
Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation.
PloS one
·
08 Apr 2011
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pubmed:21494628