Dr. Sam Chen is a Bioinformatics Scientist in the Brain Tumor Institute Bioinformatics Core at Children’s National Hospital (CNH) broadly supporting investigators within the Center for Cancer and Immunology Research (CCIR) at Children’s National.
Before starting at CNH, Dr. Chen worked as a Bioinformatics Scientist at Dyno Therapeutics where he designed and executed production scale single nucleus RNA-Seq (snRNA-Seq) QC and analytical workflows. There, he also spearheaded the evaluation and validation of AI-designed AAV gene therapy vectors, contributing to product launches and licensing agreements.
Prior to his work at Dyno, Dr. Chen interned at Genentech, where he contributed to the development of Epiregulon, an R package to infer transcription factor (TF) activity in single cells through integrative modelling of multi-omics data.
Dr. Chen completed his Ph.D. in Biomedical Informatics at Northwestern University. His dissertation research focused on multi-omics analyses (scRNA-seq, bulk RNA-seq, CITE-seq, ATAC-seq) to characterize macrophage heterogeneity and inflammatory pathways in rheumatoid arthritis and liver cholestasis.
Dr. Chen is passionate about applying single-cell and multi-omics approaches to advance precision diagnostics and therapies for pediatric cancer and immune diseases. Outside of the lab, Sam enjoys traveling, watching baseball, and searching for good food.
Search for Shang-Yang (Sam) Chen, Ph.D.'s papers on the Publications page